A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Integrin trafficking in cells and tissues
Tekijät: Paulina Moreno-Layseca, Jaroslav Icha, Hellyeh Hamidi, Johanna Ivaska
Julkaisuvuosi: 2019
Journal: Nature Cell Biology
Tietokannassa oleva lehden nimi: Nature cell biology
Lehden akronyymi: Nat Cell Biol
Vuosikerta: 21
Numero: 2
Aloitussivu: 122
Lopetussivu: 132
Sivujen määrä: 11
ISSN: 1465-7392
eISSN: 1476-4679
DOI: https://doi.org/10.1038/s41556-018-0223-z
Tiivistelmä
Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is accomplished primarily through the integrin family of cell-surface receptors. Integrins are internalized and enter the endocytic-exocytic pathway before being recycled back to the plasma membrane. The trafficking of this extensive protein family is regulated in multiple context-dependent ways to modulate integrin function in the cell. Here, we discuss recent advances in understanding the mechanisms and cellular roles of integrin endocytic trafficking.
Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is accomplished primarily through the integrin family of cell-surface receptors. Integrins are internalized and enter the endocytic-exocytic pathway before being recycled back to the plasma membrane. The trafficking of this extensive protein family is regulated in multiple context-dependent ways to modulate integrin function in the cell. Here, we discuss recent advances in understanding the mechanisms and cellular roles of integrin endocytic trafficking.
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