Insulin secretion and sensitivity in the prediction of type 1 diabetes in children with advanced beta-cell autoimmunity



: Siljander HT, Hermann R, Hekkala A, Lahde J, Tanner L, Keskinen P, Ilonen J, Simell O, Veijola R, Knip M

Publisher: BIOSCIENTIFICA LTD

: 2013

: European Journal of Endocrinology

: EUROPEAN JOURNAL OF ENDOCRINOLOGY

: EUR J ENDOCRINOL

: 4

: 169

: 4

: 479

: 485

: 7

: 0804-4643

DOI: https://doi.org/10.1530/EJE-13-0206


Conclusions: Young age, higher BMI SDS, reduced FPIR and higher levels of IAA and IA-2A predicted T1D in young children with HLA-DQB1-conferred disease susceptibility and advanced beta-cell autoimmunity. Disease risk estimates were successfully stratified by the assessment of metabolic status and BMI. The role of insulin resistance as an accelerator of the disease process was minor.




Last updated on 2024-26-11 at 21:47