Insulin secretion and sensitivity in the prediction of type 1 diabetes in children with advanced beta-cell autoimmunity - UTU Research Portal

A1 Refereed original research article in a scientific journal

Insulin secretion and sensitivity in the prediction of type 1 diabetes in children with advanced beta-cell autoimmunity

Authors: Siljander HT, Hermann R, Hekkala A, Lahde J, Tanner L, Keskinen P, Ilonen J, Simell O, Veijola R, Knip M

Publisher: BIOSCIENTIFICA LTD

Publication year: 2013

Journal: European Journal of Endocrinology

Journal name in source: EUROPEAN JOURNAL OF ENDOCRINOLOGY

Journal acronym: EUR J ENDOCRINOL

Number in series: 4

Volume: 169

Issue: 4

First page : 479

Last page: 485

Number of pages: 7

ISSN: 0804-4643

DOI: https://doi.org/10.1530/EJE-13-0206

Abstract

Conclusions: Young age, higher BMI SDS, reduced FPIR and higher levels of IAA and IA-2A predicted T1D in young children with HLA-DQB1-conferred disease susceptibility and advanced beta-cell autoimmunity. Disease risk estimates were successfully stratified by the assessment of metabolic status and BMI. The role of insulin resistance as an accelerator of the disease process was minor.