Transmitters contributing to the voiding contraction in female rats

: Streng T, Talo A, Andersson KE

Publisher: BLACKWELL PUBLISHING LTD

: 2004

BJU International

BJU INTERNATIONAL

: BJU INT

: 94

: 6

: 910

: 914

: 5

: 1464-4096

DOI: https://doi.org/10.1111/j.1464-410X.2004.05058.x

CONCLUSIONS ATP contributes mainly to the initial and acetylcholine to the later phases of the voiding cycle in the rat. Neither agent abolished the IHPFOs; even after blocking the receptors for one transmitter and in the presence of IPHFOs, the bladder can still empty. However, if both receptors are blocked, overflow incontinence develops, suggesting that even if further transmitters are taking part in the voiding contraction, their physiological significance is questionable.