A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Role of Follicle-Stimulating Hormone in Spermatogenesis
Tekijät: Olayiwola O. Oduwole, Hellevi Peltoketo, Ilpo T. Huhtaniemi
Kustantaja: FRONTIERS MEDIA SA
Julkaisuvuosi: 2018
Journal: Frontiers in Endocrinology
Tietokannassa oleva lehden nimi: FRONTIERS IN ENDOCRINOLOGY
Lehden akronyymi: FRONT ENDOCRINOL
Artikkelin numero: ARTN 763
Vuosikerta: 9
Sivujen määrä: 11
ISSN: 1664-2392
DOI: https://doi.org/10.3389/fendo.2018.00763
Verkko-osoite: https://www.frontiersin.org/articles/10.3389/fendo.2018.00763
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/37625934
Spermatogenesis is a concerted sequence of events duringmaturation of spermatogonia into spermatozoa. The process involves differential gene-expression and cell-cell interplay regulated by the key endocrine stimuli, i.e., follicle-stimulating hormone (FSH) and luteinizing hormone (LH)-stimulated testosterone. FSH affects independently and in concert with testosterone, the proliferation, maturation and function of the supporting Sertoli cells that produce regulatory signals and nutrients for the maintenance of developing germ cells. Rodents are able to complete spermatogenesis without FSH stimulus, but its deficiency significantly decreases sperm quantity. Men carrying loss-of-function mutation in the gene encoding the ligand (FSHB) or its receptor (FSHR) present, respectively, with azoospermia or suppressed spermatogenesis. Recently, the importance of high intratesticular testosterone concentration for spermatogenesis has been questioned. It was established that it can be completed at minimal intratesticular concentration of the hormone. Furthermore, we recently demonstrated that very robust constitutive FSHR action can rescue spermatogenesis and fertility of mice even when the testosterone stimulus is completely blocked. The clinical relevance of these findings concerns a new strategy of high-dose FSH in treatment of spermatogenic failure.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
