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Filopodia: molecular architecture and cellular functions
Tekijät: Mattila PK, Lappalainen P
Kustantaja: NATURE PUBLISHING GROUP
Julkaisuvuosi: 2008
Journal: Nature Reviews Molecular Cell Biology
Tietokannassa oleva lehden nimi: NATURE REVIEWS MOLECULAR CELL BIOLOGY
Lehden akronyymi: NAT REV MOL CELL BIO
Vuosikerta: 9
Numero: 6
Aloitussivu: 446
Lopetussivu: 454
Sivujen määrä: 9
ISSN: 1471-0072
DOI: https://doi.org/10.1038/nrm2406
Tiivistelmä
Filopodia are thin, actin-rich plasma-membrane protrusions that function as antennae for cells to probe their environment. Consequently, filopodia have an important role in cell migration, neurite outgrowth and wound healing and serve as precursors for dendritic spines in neurons. The initiation and elongation of filopodia depend on the precisely regulated polymerization, convergence and crosslinking of actin filaments. The increased understanding of the functions of various actin-associated proteins during the initiation and elongation of filopodia has provided new information on the mechanisms of filopodia formation in distinct cell types.
Filopodia are thin, actin-rich plasma-membrane protrusions that function as antennae for cells to probe their environment. Consequently, filopodia have an important role in cell migration, neurite outgrowth and wound healing and serve as precursors for dendritic spines in neurons. The initiation and elongation of filopodia depend on the precisely regulated polymerization, convergence and crosslinking of actin filaments. The increased understanding of the functions of various actin-associated proteins during the initiation and elongation of filopodia has provided new information on the mechanisms of filopodia formation in distinct cell types.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
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