A1 Refereed original research article in a scientific journal
Filopodia: molecular architecture and cellular functions
Authors: Mattila PK, Lappalainen P
Publisher: NATURE PUBLISHING GROUP
Publication year: 2008
Journal: Nature Reviews Molecular Cell Biology
Journal name in source: NATURE REVIEWS MOLECULAR CELL BIOLOGY
Journal acronym: NAT REV MOL CELL BIO
Volume: 9
Issue: 6
First page : 446
Last page: 454
Number of pages: 9
ISSN: 1471-0072
DOI: https://doi.org/10.1038/nrm2406
Abstract
Filopodia are thin, actin-rich plasma-membrane protrusions that function as antennae for cells to probe their environment. Consequently, filopodia have an important role in cell migration, neurite outgrowth and wound healing and serve as precursors for dendritic spines in neurons. The initiation and elongation of filopodia depend on the precisely regulated polymerization, convergence and crosslinking of actin filaments. The increased understanding of the functions of various actin-associated proteins during the initiation and elongation of filopodia has provided new information on the mechanisms of filopodia formation in distinct cell types.
Filopodia are thin, actin-rich plasma-membrane protrusions that function as antennae for cells to probe their environment. Consequently, filopodia have an important role in cell migration, neurite outgrowth and wound healing and serve as precursors for dendritic spines in neurons. The initiation and elongation of filopodia depend on the precisely regulated polymerization, convergence and crosslinking of actin filaments. The increased understanding of the functions of various actin-associated proteins during the initiation and elongation of filopodia has provided new information on the mechanisms of filopodia formation in distinct cell types.
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