A1 Refereed original research article in a scientific journal

Potent pairing: ensemble of long short-term memory networks and support vector machine for chemical-protein relation extraction




AuthorsFarrokh Mehryary, Jari Björne, Tapio Salakoski, Filip Ginter

PublisherOxford University Press

Publication year2018

JournalDatabase: The Journal of Biological Databases and Curation

Article numberbay120

Volume2018

Number of pages23

ISSN1758-0463

eISSN1758-0463

DOIhttps://doi.org/10.1093/database/bay120

Web address https://academic.oup.com/database/article/doi/10.1093/database/bay120/5255148

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/37351936


Abstract

Biomedical researchers regularly discover new interactions between chemical compounds/drugs and genes/proteins, and report them in research literature. Having knowledge about these interactions is crucially important in many research areas such as precision medicine and drug discovery. The BioCreative VI Task 5 (CHEMPROT) challenge promotes the development and evaluation of computer systems that can automatically recognize and extract statements of such interactions from biomedical literature. We participated in this challenge with a Support Vector Machine (SVM) system and a deep learning-based system (ST-ANN), and achieved an F-score of 60.99 for the task. After the shared task, we have significantly improved the performance of the ST-ANN system. Additionally, we have developed a new deep learning-based system (I-ANN) that considerably outperforms the ST-ANN system. Both ST-ANN and I-ANN systems are centered around training an ensemble of artificial neural networks and utilizing different bidirectional Long Short-Term Memory (LSTM) chains for representing the shortest dependency path and/or the full sentence. By combining the predictions of the SVM and the I-ANN systems, we achieved an F-score of 63.10 for the task, improving our previous F-score by 2.11 percentage points. Our systems are fully open-source and publicly available. We highlight that the systems we present in this study are not applicable only to the BioCreative VI Task 5, but can be effortlessly re-trained to extract any types of relations of interest, with no modifications of the source code required, if a manually annotated corpus is provided as training data in a specific file format.


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