A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study




TekijätKananen L, Marttila S, Nevalainen T, Jylhava J, Mononen N, Kahonen M, Raitakari OT, Lehtimaki T, Hurme M

KustantajaBIOMED CENTRAL LTD

Julkaisuvuosi2016

JournalBMC Genomics

Tietokannassa oleva lehden nimiBMC GENOMICS

Lehden akronyymiBMC GENOMICS

Artikkelin numeroARTN 103

Vuosikerta17

Sivujen määrä12

ISSN1471-2164

DOIhttps://doi.org/10.1186/s12864-016-2421-z


Tiivistelmä

Conclusions: Here we report that aging-associated DNA methylation features can be identified in a middle-aged population with an age range of only 9 years. A great majority of these sites have been previously reported as aging-associated in a population aged 19 to 90 years. Aging is associated with different types of changes in DNA methylation, clock-like as well as random. We speculate that the a-CpGs identified here in a population with a narrow age-range represent clock-like changes, as they showed concordant methylation behavior in population spanning whole adulthood as well.




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