A1 Refereed original research article in a scientific journal

Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study




AuthorsKananen L, Marttila S, Nevalainen T, Jylhava J, Mononen N, Kahonen M, Raitakari OT, Lehtimaki T, Hurme M

PublisherBIOMED CENTRAL LTD

Publication year2016

JournalBMC Genomics

Journal name in sourceBMC GENOMICS

Journal acronymBMC GENOMICS

Article numberARTN 103

Volume17

Number of pages12

ISSN1471-2164

DOIhttps://doi.org/10.1186/s12864-016-2421-z


Abstract

Conclusions: Here we report that aging-associated DNA methylation features can be identified in a middle-aged population with an age range of only 9 years. A great majority of these sites have been previously reported as aging-associated in a population aged 19 to 90 years. Aging is associated with different types of changes in DNA methylation, clock-like as well as random. We speculate that the a-CpGs identified here in a population with a narrow age-range represent clock-like changes, as they showed concordant methylation behavior in population spanning whole adulthood as well.




Last updated on 2024-26-11 at 16:16