A1 Refereed original research article in a scientific journal
Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study
Authors: Kananen L, Marttila S, Nevalainen T, Jylhava J, Mononen N, Kahonen M, Raitakari OT, Lehtimaki T, Hurme M
Publisher: BIOMED CENTRAL LTD
Publication year: 2016
Journal: BMC Genomics
Journal name in source: BMC GENOMICS
Journal acronym: BMC GENOMICS
Article number: ARTN 103
Volume: 17
Number of pages: 12
ISSN: 1471-2164
DOI: https://doi.org/10.1186/s12864-016-2421-z
Conclusions: Here we report that aging-associated DNA methylation features can be identified in a middle-aged population with an age range of only 9 years. A great majority of these sites have been previously reported as aging-associated in a population aged 19 to 90 years. Aging is associated with different types of changes in DNA methylation, clock-like as well as random. We speculate that the a-CpGs identified here in a population with a narrow age-range represent clock-like changes, as they showed concordant methylation behavior in population spanning whole adulthood as well.