A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
The dose response principle from philosophy to modern toxicology: The impact of ancient philosophy and medicine in modern toxicology science
Tekijät: Tsatsakis AM, Vassilopoulou L, Kovatsi L, Tsitsimpikou C, Karamanou M, Leon G, Liesivuori J, Hayes AW, Spandidos DA
Kustantaja: ELSEVIER SCIENCE BV
Julkaisuvuosi: 2018
Journal: Toxicology Reports
Tietokannassa oleva lehden nimi: TOXICOLOGY REPORTS
Lehden akronyymi: TOXICOL REP
Vuosikerta: 5
Aloitussivu: 1107
Lopetussivu: 1113
Sivujen määrä: 7
ISSN: 2214-7500
eISSN: 2214-7500
DOI: https://doi.org/10.1016/j.toxrep.2018.10.001
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/37227279
Since ancient times the concept of dose response, from a toxicological perspective, has been a matter of concern. Already by the 8th century BC and over the years, many enlightened people have attempted to interpret this phenomenon, observing and coming across its results and practical implementation through exposure to chemical substances, either from natural or synthetic sources. Nowadays, the environmental exposure of human populations to chemicals in terms of quantity and quality might differ. Nevertheless, dose response still remains an issue joining hands with scientific and technological progress. The aim of the present review is not only to briefly recount the history of the dose response concept, from ancient time theories to novel approaches, but also to draw the outline of challenges and requirements toxicology science needs to fulfill.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
