Voiding effects mediated by alpha(2)-adrenoceptors in the anaesthetized male rat

: Streng T, Santti R, Andersson KE

Publisher: WILEY-BLACKWELL

: 2010

: BJU International

: BJU INTERNATIONAL

: BJU INT

: 10

: 106

: 10

: 1546

: 1549

: 4

: 1464-4096

DOI: https://doi.org/10.1111/j.1464-410X.2010.09228.x

Stimulation and blockade of alpha(2)-ARs have a significant effect on lower urinary tract function. If the data from this rat model are also valid in humans, a study of the effects of atipamezole on urethral sphincter activity and urethral pressures in humans would be of interest, and might show therapeutic potential of the drug.