Voiding effects mediated by alpha(2)-adrenoceptors in the anaesthetized male rat

: Streng T, Santti R, Andersson KE

Publisher: WILEY-BLACKWELL

: 2010

BJU International

: BJU INTERNATIONAL

: BJU INT

: 10

: 106

: 10

: 1546

: 1549

: 4

: 1464-4096

DOI: https://doi.org/10.1111/j.1464-410X.2010.09228.x

Stimulation and blockade of alpha(2)-ARs have a significant effect on lower urinary tract function. If the data from this rat model are also valid in humans, a study of the effects of atipamezole on urethral sphincter activity and urethral pressures in humans would be of interest, and might show therapeutic potential of the drug.

cystometry, LUT function, male rat, urodynamics