A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Probabilistic Analysis of Probe Reliability in Differential Gene Expression Studies with Short Oligonucleotide Arrays
Tekijät: Lahti L, Elo LL, Aittokallio T, Kaski S
Kustantaja: IEEE COMPUTER SOC
Julkaisuvuosi: 2011
Journal: IEEE/ACM Transactions on Computational Biology and Bioinformatics
Tietokannassa oleva lehden nimi: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
Lehden akronyymi: IEEE ACM T COMPUT BI
Numero sarjassa: 1
Vuosikerta: 8
Numero: 1
Aloitussivu: 217
Lopetussivu: 225
Sivujen määrä: 9
ISSN: 1545-5963
DOI: https://doi.org/10.1109/TCBB.2009.38
Tiivistelmä
Probe defects are a major source of noise in gene expression studies. While existing approaches detect noisy probes based on external information such as genomic alignments, we introduce and validate a targeted probabilistic method for analyzing probe reliability directly from expression data and independently of the noise source. This provides insights into the various sources of probe-level noise and gives tools to guide probe design.
Probe defects are a major source of noise in gene expression studies. While existing approaches detect noisy probes based on external information such as genomic alignments, we introduce and validate a targeted probabilistic method for analyzing probe reliability directly from expression data and independently of the noise source. This provides insights into the various sources of probe-level noise and gives tools to guide probe design.
Turun yliopiston Tutkimustietojärjestelmän portaali