A2 Review article in a scientific journal

Hydrolytic Reactions of Nucleoside Phosphoramidates: Kinetics and Mechanisms




List of Authors: Lonnberg T, Ora M, Lonnberg H

Publisher: BENTHAM SCIENCE PUBL LTD

Publication year: 2010

Journal: Mini-Reviews in Organic Chemistry

Journal name in source: MINI-REVIEWS IN ORGANIC CHEMISTRY

Journal acronym: MINI-REV ORG CHEM

Number in series: 1

Volume number: 7

Issue number: 1

Number of pages: 11

ISSN: 1570-193X


Abstract
Nucleoside phosphoramidates have recently received considerable interest as pro-drugs of antiviral analogs of nucleoside monophosphates and as constituents of antisense oligonucleotides. For these reasons, the hydrolytic stability of phosphoramidate linkages also is of interest. The present paper gives a survey of the kinetic and mechanistic studies with phosphoramidates, above all the studies with nucleoside phosphoramidates.


Research Areas


Last updated on 2021-24-06 at 08:28