Human Telomeric DNA Sequence-Specific Cleaving by G-Quadruplex Formation



: Xu Y, Suzuki Y, Lonnberg T, Komiyama M

Publisher: AMER CHEMICAL SOC

: 2009

Journal of the American Chemical Society

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

: J AM CHEM SOC

: 131

: 8

: 2871

: 2874

: 4

: 0002-7863

DOI: https://doi.org/10.1021/ja807313x


Telomere is an emerging target for the treatment of human cancers. Here, we report a structure-based approach to sequence-specific cleaving of human telomeric DNA by G-quadruplex formation. Oligonucleotide with multiphosphonate [DNA-EDTP-Ce(IV)] at the 5' end binds to human telomere DNA by G-quadruplex formation and causes a sequence-specific strand break. These results provide the first proof of concept for targeting the human telomere DNA based on G-quadruplex formation, and this may serve as a starting point for the design of more efficient telomere sequence-specific cleaving reagents by G-quadruplex formation.



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