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Human Telomeric DNA Sequence-Specific Cleaving by G-Quadruplex Formation
Tekijät: Xu Y, Suzuki Y, Lonnberg T, Komiyama M
Kustantaja: AMER CHEMICAL SOC
Julkaisuvuosi: 2009
Lehti:Journal of the American Chemical Society
Tietokannassa oleva lehden nimiJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Lehden akronyymi: J AM CHEM SOC
Vuosikerta: 131
Numero: 8
Aloitussivu: 2871
Lopetussivu: 2874
Sivujen määrä: 4
ISSN: 0002-7863
DOI: https://doi.org/10.1021/ja807313x
Tiivistelmä
Telomere is an emerging target for the treatment of human cancers. Here, we report a structure-based approach to sequence-specific cleaving of human telomeric DNA by G-quadruplex formation. Oligonucleotide with multiphosphonate [DNA-EDTP-Ce(IV)] at the 5' end binds to human telomere DNA by G-quadruplex formation and causes a sequence-specific strand break. These results provide the first proof of concept for targeting the human telomere DNA based on G-quadruplex formation, and this may serve as a starting point for the design of more efficient telomere sequence-specific cleaving reagents by G-quadruplex formation.
Telomere is an emerging target for the treatment of human cancers. Here, we report a structure-based approach to sequence-specific cleaving of human telomeric DNA by G-quadruplex formation. Oligonucleotide with multiphosphonate [DNA-EDTP-Ce(IV)] at the 5' end binds to human telomere DNA by G-quadruplex formation and causes a sequence-specific strand break. These results provide the first proof of concept for targeting the human telomere DNA based on G-quadruplex formation, and this may serve as a starting point for the design of more efficient telomere sequence-specific cleaving reagents by G-quadruplex formation.
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