A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Development and descent of the testis in relation to cryptorchidism
Tekijät: Virtanen HE, Cortes D, Rajpert-De Meyts E, Ritzén EM, Nordenskjöld A, Skakkebaek NE, Toppari J
Julkaisuvuosi: 2007
Lehti:: Acta Paediatrica
Tietokannassa oleva lehden nimi: Acta paediatrica (Oslo, Norway : 1992)
Lehden akronyymi: Acta Paediatr
Vuosikerta: 96
Numero: 5
Aloitussivu: 622
Lopetussivu: 7
Sivujen määrä: 6
ISSN: 0803-5253
DOI: https://doi.org/10.1111/j.1651-2227.2007.00244.x
Tiivistelmä
The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development.\nSince testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis.\nUNLABELLED\nCONCLUSION
The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development.\nSince testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis.\nUNLABELLED\nCONCLUSION
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