A2 Refereed review article in a scientific journal
Development and descent of the testis in relation to cryptorchidism
Authors: Virtanen HE, Cortes D, Rajpert-De Meyts E, Ritzén EM, Nordenskjöld A, Skakkebaek NE, Toppari J
Publication year: 2007
Journal:: Acta Paediatrica
Journal name in source: Acta paediatrica (Oslo, Norway : 1992)
Journal acronym: Acta Paediatr
Volume: 96
Issue: 5
First page : 622
Last page: 7
Number of pages: 6
ISSN: 0803-5253
DOI: https://doi.org/10.1111/j.1651-2227.2007.00244.x
Abstract
The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development.\nSince testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis.\nUNLABELLED\nCONCLUSION
The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development.\nSince testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis.\nUNLABELLED\nCONCLUSION
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