Host CD73 impairs anti-tumor immunity

: Salmi M, Jalkanen S

Publisher: LANDES BIOSCIENCE

: 2012

: OncoImmunology

: ONCOIMMUNOLOGY

: 2

: 1

: 2

: 247

: 248

: 2

: 2162-4011

DOI: https://doi.org/10.4161/onci.1.2.18310

The enzymatic activity of CD73 produces immune-suppressing adenosine. In CD73 deficient hosts, tumor growth and tumor infiltration by Tregs and type 2 immunosuppressive macrophages is reduced. Pharmacological inhibition of CD73 in wild-type mice has similar tumor-suppressing effects. Host CD73 on leukocytes and endothelial cells is thus detrimental for the anti-tumor immunity.