A1 Refereed original research article in a scientific journal
Host CD73 impairs anti-tumor immunity
Authors: Salmi M, Jalkanen S
Publisher: LANDES BIOSCIENCE
Publication year: 2012
Journal: OncoImmunology
Journal name in source: ONCOIMMUNOLOGY
Journal acronym: ONCOIMMUNOLOGY
Number in series: 2
Volume: 1
Issue: 2
First page : 247
Last page: 248
Number of pages: 2
ISSN: 2162-4011
DOI: https://doi.org/10.4161/onci.1.2.18310
Abstract
The enzymatic activity of CD73 produces immune-suppressing adenosine. In CD73 deficient hosts, tumor growth and tumor infiltration by Tregs and type 2 immunosuppressive macrophages is reduced. Pharmacological inhibition of CD73 in wild-type mice has similar tumor-suppressing effects. Host CD73 on leukocytes and endothelial cells is thus detrimental for the anti-tumor immunity.
The enzymatic activity of CD73 produces immune-suppressing adenosine. In CD73 deficient hosts, tumor growth and tumor infiltration by Tregs and type 2 immunosuppressive macrophages is reduced. Pharmacological inhibition of CD73 in wild-type mice has similar tumor-suppressing effects. Host CD73 on leukocytes and endothelial cells is thus detrimental for the anti-tumor immunity.
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