A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Impact of dietary intervention, sex, and apolipoprotein E phenotype on tracking of serum lipids and apolipoproteins in 1-to 5-year-old children - The Special Turku Coronary Risk Factor Intervention Project (STRIP)
Tekijät: Rask-Nissila L, Jokinen E, Viikari J, Tammi A, Ronnemaa T, Marniemi J, Salo P, Routi T, Helenius H, Valimaki I, Simell O
Kustantaja: LIPPINCOTT WILLIAMS & WILKINS
Julkaisuvuosi: 2002
Journal: Arteriosclerosis, Thrombosis, and Vascular Biology
Tietokannassa oleva lehden nimi: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Lehden akronyymi: ARTERIOSCL THROM VAS
Vuosikerta: 22
Numero: 3
Aloitussivu: 492
Lopetussivu: 498
Sivujen määrä: 7
ISSN: 1079-5642
DOI: https://doi.org/10.1161/hq0302.104516
The effects of dietary intervention, sex, and apolipoprotein E phenotype on tracking of serum lipid values in young children have remained poorly characterized. We investigated these associations in 1062 infants who were randomized into control and intervention groups (n=522 and n=540, respectively) at age 7 months; the intervention group received counseling aimed at maintaining a low-saturated fat, low-cholesterol diet. In 519 children in the control (n=254) and intervention (n=265) groups, serum lipid values were studied annually between 13 months and 5 years of age. In all children, tracking was strongest for the ratio of high density lipoprotein (RDL) cholesterol to total cholesterol; when a 13-month-old child belonged to the lowest quartile of the distribution, the odds ratio for belonging to the same quartile at older ages was 39.0 (95% CI 23.1 to 66.0). Dietary intervention did not influence the tracking of serum lipids. Tracking of HDL cholesterol was stronger in the boys than in the girls (P=0.018). Tracking of non-HDL cholesterol and apolipoprotein B in the children with phenotypes E2/3 or E3/3 was stronger than that in the other children (P=0.031 and P=0.014, respectively). In conclusion, the apolipoprotein E phenotype strongly influences tracking of non-HDL cholesterol and apolipoprotein B values in early childhood, whereas dietary intervention had no effect on tracking of any of the lipids. A child's sex influenced tracking only of HDL cholesterol, with boys showing stronger tracking.
