A1 Refereed original research article in a scientific journal

Impact of dietary intervention, sex, and apolipoprotein E phenotype on tracking of serum lipids and apolipoproteins in 1-to 5-year-old children - The Special Turku Coronary Risk Factor Intervention Project (STRIP)




AuthorsRask-Nissila L, Jokinen E, Viikari J, Tammi A, Ronnemaa T, Marniemi J, Salo P, Routi T, Helenius H, Valimaki I, Simell O

PublisherLIPPINCOTT WILLIAMS & WILKINS

Publication year2002

JournalArteriosclerosis, Thrombosis, and Vascular Biology

Journal name in sourceARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Journal acronymARTERIOSCL THROM VAS

Volume22

Issue3

First page 492

Last page498

Number of pages7

ISSN1079-5642

DOIhttps://doi.org/10.1161/hq0302.104516(external)


Abstract
The effects of dietary intervention, sex, and apolipoprotein E phenotype on tracking of serum lipid values in young children have remained poorly characterized. We investigated these associations in 1062 infants who were randomized into control and intervention groups (n=522 and n=540, respectively) at age 7 months; the intervention group received counseling aimed at maintaining a low-saturated fat, low-cholesterol diet. In 519 children in the control (n=254) and intervention (n=265) groups, serum lipid values were studied annually between 13 months and 5 years of age. In all children, tracking was strongest for the ratio of high density lipoprotein (RDL) cholesterol to total cholesterol; when a 13-month-old child belonged to the lowest quartile of the distribution, the odds ratio for belonging to the same quartile at older ages was 39.0 (95% CI 23.1 to 66.0). Dietary intervention did not influence the tracking of serum lipids. Tracking of HDL cholesterol was stronger in the boys than in the girls (P=0.018). Tracking of non-HDL cholesterol and apolipoprotein B in the children with phenotypes E2/3 or E3/3 was stronger than that in the other children (P=0.031 and P=0.014, respectively). In conclusion, the apolipoprotein E phenotype strongly influences tracking of non-HDL cholesterol and apolipoprotein B values in early childhood, whereas dietary intervention had no effect on tracking of any of the lipids. A child's sex influenced tracking only of HDL cholesterol, with boys showing stronger tracking.



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