A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Determinants of Myocardial Strain in Experimental Chronic Myocardial Infarction
Tekijät: Haitham Ballo, Miikka Tarkia, Matti Haavisto, Christoffer Stark, Marjatta Strandberg, Tommi Vähäsilta, Virva Saunavaara, Tuula Tolvanen, Ville-Veikko Hynninen, Timo Savunen, Anne Roivainen, Juhani Knuuti, Antti Saraste
Julkaisuvuosi: 2019
Journal: Ultrasound in Medicine and Biology
Vuosikerta: 45
Numero: 2
Aloitussivu: 568
Lopetussivu: 578
Sivujen määrä: 11
ISSN: 0301-5629
DOI: https://doi.org/10.1016/j.ultrasmedbio.2018.10.005
Verkko-osoite: https://www.umbjournal.org/article/S0301-5629(18)30433-2/fulltext
We evaluated the relationships between regional myocardial strain
measured by speckle tracking echocardiography and viability, fibrosis,
hypertrophy and oxygen consumption in the infarcted or remote myocardium
in a pig model of chronic myocardial infarction (MI). Thirteen farm
pigs with surgical occlusion of the left anterior descending coronary
artery and five sham-operated pigs were studied 3 mo post-MI. Computed
tomography revealed significant left ventricle remodeling. Reduced
radial or circumferential strain identified areas of transmural
infarction (area under the curve: 0.82 and 0.79, respectively). In the
remote non-infarcted area, radial strain correlated inversely with the
amount of fibrosis (r = -0.66, p = 0.04) and myocyte hypertrophy
(r = -0.68, p = 0.03). Radial strain rate inversely correlated with
myocardial resting oxygen consumption assessed with 11C-labeled
acetate positron emission tomography (r = -0.71, p = 0.006). In
conclusion, myocardial strain and strain rate reflect fibrosis,
hypertrophy and oxygen consumption of the remote areas after MI.
