A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
EGFR gene copy number decreases during anti-EGFR antibody therapy in colorectal cancer
Tekijät: Eva-Maria Birkman, Tuulia Avoranta, Annika Ålgars, Eija Korkeila, Minnamaija Lintunen, Laura Lahtinen, Teijo Kuopio, Raija Ristamäki, Olli Carpén, Jari Sundström
Kustantaja: W.B. Saunders
Julkaisuvuosi: 2018
Journal: Human Pathology
Tietokannassa oleva lehden nimi: Human Pathology
Vuosikerta: 82
Aloitussivu: 163
Lopetussivu: 171
Sivujen määrä: 9
ISSN: 0046-8177
eISSN: 1532-8392
DOI: https://doi.org/10.1016/j.humpath.2018.07.028
Verkko-osoite: https://www.sciencedirect.com/science/article/pii/S004681771830296X
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/36702726
Epidermal growth factor receptor (EGFR) gene copy number (GCN) increase is associated with a favorable anti-EGFR antibody treatment response in RAS wild-type metastatic colorectal cancer. However, there are limited and comparative data regarding the EGFR GCN in primary colorectal cancer tumors and corresponding metastases or the effect of anti-EGFR antibody treatment on EGFR GCN in recurrent disease. In addition, little is known about the potential EGFR GCN changes during anti-EGFR therapy in comparison with other treatment regimens. EGFR GCN was analyzed by EGFR immunohistochemistry-guided silver in situ hybridization in primary and corresponding recurrent local or metastatic tumors from 80 colorectal cancer patients. GCN levels were compared between KRAS wild-type patients having received anti-EGFR therapy and patients having received other forms of treatment after primary surgery. The EGFR GCN decrease between primary and recurrent tumors was more pronounced among the anti–EGFR-treated patients than among patients not treated with anti-EGFR therapy (P = .047). None of the patients experiencing an EGFR GCN increase of at least 1.0 between the primary and recurrent tumors were treated with anti-EGFR antibodies. When including only patients with distant metastases, an EGFR GCN decrease of at least 1.0 was more common among the anti–EGFR-treated patients than among patients not treated with anti-EGFR therapy (P = .028). Our results suggest that anti-EGFR antibody treatment is associated with EGFR GCN decrease between the primary and recurrent colorectal adenocarcinomas, whereas no GCN change is observed among patients receiving other forms of treatment after primary surgery.
Ladattava julkaisu This is an electronic reprint of the original article. |