A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Steroid-responsive encephalopathy with a peculiar CSF biomarker profile in an 89-year-old man




TekijätSipilä J., Rissanen E., Korpela J., Päivärinta M.

KustantajaOxford University Press

Julkaisuvuosi2018

JournalOxford Medical Case Reports

Tietokannassa oleva lehden nimiOxford Medical Case Reports

Artikkelin numeroomy073

Vuosikerta2018

Numero10

Aloitussivu339

Lopetussivu341

ISSN2053-8855

eISSN2053-8855

DOIhttps://doi.org/10.1093/omcr/omy073

Verkko-osoitehttps://academic.oup.com/omcr/article/2018/10/omy073/5106147

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/36683014


Tiivistelmä

Being treatable, steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), or Hashimoto’s encephalopathy, should be distinguished from untreatable conditions. Our patient was a previously healthy 89-year-old man, who presented with cognitive and balance deterioration over several months. His cerebrospinal fluid (CSF) examination was positive for protein 14-3-3 but no other test suggested Creutzfeldt–Jacob disease. His condition improved markedly, although not fully, with intravenous corticosteroids. In control CSF sampling, protein 14-3-3 was negative but a biomarker signature consistent with Alzheimer’s disease was observed. SREAT should be considered also in the very elderly in case of subacute encephalopathy.


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