Lack of hybridization between Yersinia enterocolitica and HLA-B27 DNA



: Viitanen AM, Lahesmaa-Rantala R, Weiss E, Toivanen A

: 1988

: Journal of Rheumatology

: The Journal of rheumatology

: J Rheumatol

: 15

: 7

: 1123

: 5

: 3

: 0315-162X


No homology was observed between Yersinia enterocolitica O:3 and HLA-B27 at DNA level when Yersinia enterocolitica chromosomal probes were hybridized with human HLA-B27 positive leukocyte DNA or in the hybridization of Yersinia DNA with HLA-B27 specific probe. Our results do not exclude the existence of molecular mimicry between Yersinia proteins and HLA-B27 antigen, since the crossreactive epitope might be a conformational determinant not detected with hybridization.



Last updated on 2024-26-11 at 17:58