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Lack of hybridization between Yersinia enterocolitica and HLA-B27 DNA
Tekijät: Viitanen AM, Lahesmaa-Rantala R, Weiss E, Toivanen A
Julkaisuvuosi: 1988
Journal: Journal of Rheumatology
Tietokannassa oleva lehden nimi: The Journal of rheumatology
Lehden akronyymi: J Rheumatol
Vuosikerta: 15
Numero: 7
Aloitussivu: 1123
Lopetussivu: 5
Sivujen määrä: 3
ISSN: 0315-162X
Tiivistelmä
No homology was observed between Yersinia enterocolitica O:3 and HLA-B27 at DNA level when Yersinia enterocolitica chromosomal probes were hybridized with human HLA-B27 positive leukocyte DNA or in the hybridization of Yersinia DNA with HLA-B27 specific probe. Our results do not exclude the existence of molecular mimicry between Yersinia proteins and HLA-B27 antigen, since the crossreactive epitope might be a conformational determinant not detected with hybridization.
No homology was observed between Yersinia enterocolitica O:3 and HLA-B27 at DNA level when Yersinia enterocolitica chromosomal probes were hybridized with human HLA-B27 positive leukocyte DNA or in the hybridization of Yersinia DNA with HLA-B27 specific probe. Our results do not exclude the existence of molecular mimicry between Yersinia proteins and HLA-B27 antigen, since the crossreactive epitope might be a conformational determinant not detected with hybridization.
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