Bacterial antigens in synovial biopsy specimens in yersinia triggered reactive arthritis



: Merilahti-Palo R, Söderström KO, Lahesmaa-Rantala R, Granfors K, Toivanen A

: 1991

: Annals of the Rheumatic Diseases

: Annals of the rheumatic diseases

: Ann Rheum Dis

: 50

: 2

: 87

: 90

: 4

: 0003-4967

DOI: https://doi.org/10.1136/ard.50.2.87


Non-viable structures of Yersinia enterocolitica O:3 were shown at the site of inflammation within mononuclear cells in the synovial membrane of eight out of 10 patients with yersinia triggered reactive arthritis. An avidin-biotin-peroxidase complex method, with a rabbit antiserum specific for Y enterocolitica O:3, was used to visualise yersinia structures. All 13 control samples were negative except for one with non-specific mast cell staining. The findings emphasise the significance of foreign material in the initiation of synovitis in reactive arthritis.



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