A1 Refereed original research article in a scientific journal
An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration
Authors: Xingzhi Liu, Hongbo Zhang, Ruoyu Cheng, Yanzheng Gu, Yin Yin, Zhiyong Sun, Guoqing Pan, Zhongbin Deng, Huilin Yang, Lianfu Deng, Wenguo Cui, Helder A. Santos, Qin Shi
Publisher: ROYAL SOC CHEMISTRY
Publication year: 2018
Journal: Materials Horizons
Journal name in source: MATERIALS HORIZONS
Journal acronym: MATER HORIZ
Volume: 5
Issue: 6
First page : 1082
Last page: 1091
Number of pages: 10
ISSN: 2051-6347
DOI: https://doi.org/10.1039/c8mh00704g
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/36479744
Antibody-based cancer immune therapy has attracted lots of research interest in recent years; however, it is greatly limited by the easy distribution and burst release of antibodies. In addition, after the clearance of the tissue, healthy tissue regeneration is another challenge for cancer treatment. Herein, we have developed a specific immunological tissue engineering scaffold using the agonistic mouse anti-human CD40 antibody (CD40mAb) incorporated into poly(l-lactide) (PLLA) electrospun fibers through the dopamine (PDA) motif (PLLA-PDA-CD40mAb). CD40mAb is successfully incorporated onto the surface of the electrospun fibrous scaffold, which is proved by immunofluorescence staining, and the PLLA-PDA-CD40mAb scaffold has an anti-tumor effect by locally releasing CD40mAb. Therefore, this immunological electrospun scaffold has very good potential to be developed as a powerful tool for localized tumor treatment, and this is the first to be reported in this area.
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