A1 Refereed original research article in a scientific journal
Proteome evolution under non-substitutable resource limitation
Authors: Tamminen M, Betz A, Pereira AL, Thali M, Matthews B, Suter MJ, Narwani A
Publisher: Nature Publishing Group
Publication year: 2018
Journal: Nature Communications
Journal name in source: Nature communications
Journal acronym: Nat Commun
Article number: 4650
Volume: 9
Number of pages: 10
ISSN: 2041-1723
eISSN: 2041-1723
DOI: https://doi.org/10.1038/s41467-018-07106-z
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/36469280
Resource limitation is a major driver of the ecological and evolutionary dynamics of organisms. Short-term responses to resource limitation include plastic changes in molecular phenotypes including protein expression. Yet little is known about the evolution of the molecular phenotype under longer-term resource limitation. Here, we combine experimental evolution of the green alga Chlamydomonas reinhardtii under multiple different non-substitutable resource limitation regimes with proteomic measurements to investigate evolutionary adaptation of the molecular phenotype. We demonstrate convergent proteomic evolution of core metabolic functions, including the Calvin-Benson cycle and gluconeogenesis, across different resource limitation environments. We do not observe proteomic changes consistent with optimized uptake of particular limiting resources. Instead, we report that adaptation proceeds in similar directions under different types of non-substitutable resource limitation. This largely convergent evolution of the expression of core metabolic proteins is associated with an improvement in the resource assimilation efficiency of nitrogen and phosphorus into biomass.
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