A1 Refereed original research article in a scientific journal
Verification of a semi-automated MRI-guided technique for non-invasive determination of the arterial input function in O-15-labeled gaseous PET
Authors: Iguchi S, Hori Y, Moriguchi T, Morita N, Yamamoto A, Koshino K, Kawashima H, Zeniya T, Enmi J, Iida H
Publisher: ELSEVIER SCIENCE BV
Publication year: 2013
Journal: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Journal name in source: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
Journal acronym: NUCL INSTRUM METH A
Volume: 702
First page : 111
Last page: 113
Number of pages: 3
ISSN: 0168-9002
DOI: https://doi.org/10.1016/j.nima.2012.08.037
A semi-automated MR-guided technique has been evaluated for non-invasive estimation of cerebral metabolic rate of oxygen (CMRO2) using the sequential administration of O-15 oxygen (O-2) and O-15 carbon dioxide (CO2) during a single PET scan. Two mathematical models, which assess the arterial input function (AIF) from time-activity curves (TAC) in the internal carotid artery region, were tested, namely one with a simple correction for the recovery coefficient (RC) and another with corrections for RC and spillover from surrounding tissues. RC was determined from MRA and black-blood image. RC was also determined from (CO)-O-15 blood volume images as a reference. RC agreed between MR-based and (CO)-O-15-PET based methods, suggesting validity of MR-based methods. Area-under-the-curve (AUC) of the early portion of estimated AIF agreed with that of measured AIF in both models. AUC of the delayed phase of estimated AIF was largely overestimated in the first model, but was sufficiently improved by the spillover correction implemented in the second model. (C) 2012 Elsevier B.V. All rights reserved.
