Zn2+-promoted hydrolysis of 3',5'-dinucleoside monophosphates and polyribonucleotides. The effect of nearest neighbours on the cleavage of phosphodiester bonds - UTU Tutkimustietojärjestelmä

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Zn2+-promoted hydrolysis of 3',5'-dinucleoside monophosphates and polyribonucleotides. The effect of nearest neighbours on the cleavage of phosphodiester bonds

Tekijät: Kuusela S, Lonnberg H

Kustantaja: MARCEL DEKKER INC

Julkaisuvuosi: 1996

Journal: Nucleosides & nucleotides

Tietokannassa oleva lehden nimi: NUCLEOSIDES & NUCLEOTIDES

Lehden akronyymi: NUCLEOS NUCLEOT

Vuosikerta: 15

Numero: 10

Aloitussivu: 1669

Lopetussivu: 1678

Sivujen määrä: 10

ISSN: 0732-8311

DOI: https://doi.org/10.1080/07328319608002466

Tiivistelmä

Pseudo first-order rate constants for the Zn2+-promoted cleavage of 15 different monophosphates, 4 different ribo homopolymers and RNA III from baker's yeast have been determined. Furthermore, the distribution of various nucleosides at the 3'-and 5'-terminus of the oligomeric hydrolysis products of RNA has been quantified. On these bases, the effect of nearest neighbours on the metal-ion-promoted hydrolysis of the internucleosidic phosphodiester bonds of RNA is discussed.