Zn2+-promoted hydrolysis of 3',5'-dinucleoside monophosphates and polyribonucleotides. The effect of nearest neighbours on the cleavage of phosphodiester bonds - UTU Research Portal

A1 Refereed original research article in a scientific journal

Zn2+-promoted hydrolysis of 3',5'-dinucleoside monophosphates and polyribonucleotides. The effect of nearest neighbours on the cleavage of phosphodiester bonds

Authors: Kuusela S, Lonnberg H

Publisher: MARCEL DEKKER INC

Publication year: 1996

Journal: Nucleosides & nucleotides

Journal name in source: NUCLEOSIDES & NUCLEOTIDES

Journal acronym: NUCLEOS NUCLEOT

Volume: 15

Issue: 10

First page : 1669

Last page: 1678

Number of pages: 10

ISSN: 0732-8311

DOI: https://doi.org/10.1080/07328319608002466

Abstract

Pseudo first-order rate constants for the Zn2+-promoted cleavage of 15 different monophosphates, 4 different ribo homopolymers and RNA III from baker's yeast have been determined. Furthermore, the distribution of various nucleosides at the 3'-and 5'-terminus of the oligomeric hydrolysis products of RNA has been quantified. On these bases, the effect of nearest neighbours on the metal-ion-promoted hydrolysis of the internucleosidic phosphodiester bonds of RNA is discussed.