A1 Refereed original research article in a scientific journal
SHORT-TERM USE OF AMOXICILLIN-CLAVULANATE DURING UPPER RESPIRATORY-TRACT INFECTION FOR PREVENTION OF ACUTE OTITIS-MEDIA
Authors: HEIKKINEN T, RUUSKANEN O, ZIEGLER T, WARIS M, PUHAKKA H
Publisher: MOSBY-ELSEVIER
Publication year: 1995
Journal: Journal of Pediatrics
Journal name in source: JOURNAL OF PEDIATRICS
Journal acronym: J PEDIATR-US
Volume: 126
Issue: 2
First page : 313
Last page: 316
Number of pages: 4
ISSN: 0022-3476
DOI: https://doi.org/10.1016/S0022-3476(95)70569-4
Abstract
We performed a randomized, double-blind, placebo-controlled study to determine whether acute otitis media could be prevented by antibiotic therapy initiated promptly after the appearance of symptoms of upper respiratory tract infection, One hundred four children aged 1 to 4 years received a 7-day course of either amoxicillin-clavulanate or placebo, Acute otitis media developed in 9 (18%) of the 50 children receiving amoxicillin clavulanate and in 12 (22%) of the 54 children receiving placebo (p = 0.59).
We performed a randomized, double-blind, placebo-controlled study to determine whether acute otitis media could be prevented by antibiotic therapy initiated promptly after the appearance of symptoms of upper respiratory tract infection, One hundred four children aged 1 to 4 years received a 7-day course of either amoxicillin-clavulanate or placebo, Acute otitis media developed in 9 (18%) of the 50 children receiving amoxicillin clavulanate and in 12 (22%) of the 54 children receiving placebo (p = 0.59).
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