Evaluation of a commercial PET tomograph-based system for the quantitative assessment of rCBF, rOEF and rCMRO(2) by using sequential administration of O-15-labeled compounds

: Shidahara M, Watabe H, Kim KM, Oka H, Sago M, Hayashi T, Miyake Y, Ishida Y, Hayashida K, Nakamura T, Iida H

Publisher: JAPANESE SOCIETY NUCLEAR MEDICINE

: 2002

: Annals of Nuclear Medicine

: ANNALS OF NUCLEAR MEDICINE

: ANN NUCL MED

: 16

: 5

: 317

: 327

: 11

: 0914-7187

DOI: https://doi.org/10.1007/BF02988616

The purpose of this study was to develop a reliable and practical strategy that generates quantitative CBF and OEF maps accurately from PET data sets obtained with O-15-tracers.Sequential sinogram data sets were acquired after the administration of O-15-tracers, and combined single-frame images were obtained. The de lay time between sampled input function and the brain was estimated from the (H2O)-O-15 study with the whole brain and the arterial time-activity curves (TACs). The whole-brain TACs were obtained from the reconstructed images (image-base method) and the sinogram data (sinogram-base method). Six methods were also evaluated for the dead-time and decay correction procedures in the process of generating a single-frame image from the dynamic sinogram.The estimated delay values were similar with both the sinogram-based and image-based methods. A lumped correction factor to a previously added single-frame sinogram caused an underestimation of CBF, OEF and CMRO2 by 16% at maximum, as compared with the correction procedure for a short sinogram. This suggested the need for a dynamic acquisition of a sinogram with a short interval. The proposed strategy provided an accurate quantification of CBF and OEF by PET with O-15-tracers.