Synthesis of modified nucleosides for incorporation of formyletheno and carboxyetheno adducts of adenine nucleosides into oligonucleotides



: Koissi N, Lonnberg H

Publisher: TAYLOR & FRANCIS INC

: 2007

 Nucleosides, Nucleotides and Nucleic Acids

: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

: NUCLEOS NUCLEOT NUCL

: 26

: 8-9

: 1203

: 1206

: 4

: 1525-7770

DOI: https://doi.org/10.1080/15257770701527836


Three protected derivatives of 1,N-6-ethenoadenine nucleosides, viz. 3-[5-O-(4,4'-dimethoxytrityl) of 7-formyl- (1) and 7-(1,2-diacetyloxypropyl)-2'-deoxyadenosine (2), and 3-[5-O-(4,4'-dimethoxytiityl)-2-O-(tert-butyldimethylsilyl)-7-(ethoxycarbonyl)adenosine (3), expected to allow introduction of formyletheno and carboxyethenoadenine adducts into oligonucleotides by the conventional phosphoramidite chemistry, have been synthesized.



Last updated on 14/10/2025 09:59:04 AM