B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä
Synthesis of modified nucleosides for incorporation of formyletheno and carboxyetheno adducts of adenine nucleosides into oligonucleotides
Tekijät: Koissi N, Lonnberg H
Kustantaja: TAYLOR & FRANCIS INC
Julkaisuvuosi: 2007
Lehti:: Nucleosides, Nucleotides and Nucleic Acids
Tietokannassa oleva lehden nimi: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Lehden akronyymi: NUCLEOS NUCLEOT NUCL
Vuosikerta: 26
Numero: 8-9
Aloitussivu: 1203
Lopetussivu: 1206
Sivujen määrä: 4
ISSN: 1525-7770
DOI: https://doi.org/10.1080/15257770701527836
Tiivistelmä
Three protected derivatives of 1,N-6-ethenoadenine nucleosides, viz. 3-[5-O-(4,4'-dimethoxytrityl) of 7-formyl- (1) and 7-(1,2-diacetyloxypropyl)-2'-deoxyadenosine (2), and 3-[5-O-(4,4'-dimethoxytiityl)-2-O-(tert-butyldimethylsilyl)-7-(ethoxycarbonyl)adenosine (3), expected to allow introduction of formyletheno and carboxyethenoadenine adducts into oligonucleotides by the conventional phosphoramidite chemistry, have been synthesized.
Three protected derivatives of 1,N-6-ethenoadenine nucleosides, viz. 3-[5-O-(4,4'-dimethoxytrityl) of 7-formyl- (1) and 7-(1,2-diacetyloxypropyl)-2'-deoxyadenosine (2), and 3-[5-O-(4,4'-dimethoxytiityl)-2-O-(tert-butyldimethylsilyl)-7-(ethoxycarbonyl)adenosine (3), expected to allow introduction of formyletheno and carboxyethenoadenine adducts into oligonucleotides by the conventional phosphoramidite chemistry, have been synthesized.
Turun yliopiston Tutkimustietojärjestelmän portaali