Prenatal Metformin Exposure in Mice Programs the Metabolic Phenotype of the Offspring during a High Fat Diet at Adulthood



: Salomaki H, Vahatalo LH, Laurila K, Jappinen NT, Penttinen AM, Ailanen L, Ilyasizadeh J, Pesonen U, Koulu M

Publisher: PUBLIC LIBRARY SCIENCE

: 2013

 PLoS ONE

: PLOS ONE

: PLOS ONE

: 2

: 8

: 2

: 12

: 1932-6203

DOI: https://doi.org/10.1371/journal.pone.0056594


Conclusions: The present study shows that prenatal metformin exposure causes long-term programming effects on the metabolic phenotype during high fat diet in mice. This should be taken into consideration when using metformin as a therapeutic agent during pregnancy.



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