A1 Refereed original research article in a scientific journal
Prenatal Metformin Exposure in Mice Programs the Metabolic Phenotype of the Offspring during a High Fat Diet at Adulthood
Authors: Salomaki H, Vahatalo LH, Laurila K, Jappinen NT, Penttinen AM, Ailanen L, Ilyasizadeh J, Pesonen U, Koulu M
Publisher: PUBLIC LIBRARY SCIENCE
Publication year: 2013
Journal: PLoS ONE
Journal name in source: PLOS ONE
Journal acronym: PLOS ONE
Number in series: 2
Volume: 8
Issue: 2
Number of pages: 12
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0056594
Abstract
Conclusions: The present study shows that prenatal metformin exposure causes long-term programming effects on the metabolic phenotype during high fat diet in mice. This should be taken into consideration when using metformin as a therapeutic agent during pregnancy.
Conclusions: The present study shows that prenatal metformin exposure causes long-term programming effects on the metabolic phenotype during high fat diet in mice. This should be taken into consideration when using metformin as a therapeutic agent during pregnancy.
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