A Semiphysiological Population Pharmacokinetic Model for Dynamic Inhibition of Liver and Gut Wall Cytochrome P450 3A by Voriconazole



: Frechen S, Junge L, Saari TI, Suleiman AA, Rokitta D, Neuvonen PJ, Olkkola KT, Fuhr U

Publisher: ADIS INT LTD

: 2013

: Clinical Pharmacokinetics

: CLINICAL PHARMACOKINETICS

: CLIN PHARMACOKINET

: 9

: 52

: 9

: 763

: 781

: 19

: 0312-5963

DOI: https://doi.org/10.1007/s40262-013-0070-9


The proposed semiphysiological modelling approach generated a mechanistic description of the complex DDI occurring at major CYP3A expression sites and thus may serve as a powerful tool to maximise information acquired from clinical DDI studies. The model has been shown to draw precise and accurate predictions. Therefore, simulations based on this kind of models may be used for various clinical scenarios to improve pharmacotherapy.



Last updated on 2024-26-11 at 18:00