A1 Refereed original research article in a scientific journal
A Semiphysiological Population Pharmacokinetic Model for Dynamic Inhibition of Liver and Gut Wall Cytochrome P450 3A by Voriconazole
Authors: Frechen S, Junge L, Saari TI, Suleiman AA, Rokitta D, Neuvonen PJ, Olkkola KT, Fuhr U
Publisher: ADIS INT LTD
Publication year: 2013
Journal: Clinical Pharmacokinetics
Journal name in source: CLINICAL PHARMACOKINETICS
Journal acronym: CLIN PHARMACOKINET
Number in series: 9
Volume: 52
Issue: 9
First page : 763
Last page: 781
Number of pages: 19
ISSN: 0312-5963
DOI: https://doi.org/10.1007/s40262-013-0070-9
Abstract
The proposed semiphysiological modelling approach generated a mechanistic description of the complex DDI occurring at major CYP3A expression sites and thus may serve as a powerful tool to maximise information acquired from clinical DDI studies. The model has been shown to draw precise and accurate predictions. Therefore, simulations based on this kind of models may be used for various clinical scenarios to improve pharmacotherapy.
The proposed semiphysiological modelling approach generated a mechanistic description of the complex DDI occurring at major CYP3A expression sites and thus may serve as a powerful tool to maximise information acquired from clinical DDI studies. The model has been shown to draw precise and accurate predictions. Therefore, simulations based on this kind of models may be used for various clinical scenarios to improve pharmacotherapy.
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