Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)
A Semiphysiological Population Pharmacokinetic Model for Dynamic Inhibition of Liver and Gut Wall Cytochrome P450 3A by Voriconazole
Julkaisun tekijät: Frechen S, Junge L, Saari TI, Suleiman AA, Rokitta D, Neuvonen PJ, Olkkola KT, Fuhr U
Kustantaja: ADIS INT LTD
Julkaisuvuosi: 2013
Journal: Clinical Pharmacokinetics
Tietokannassa oleva lehden nimi: CLINICAL PHARMACOKINETICS
Lehden akronyymi: CLIN PHARMACOKINET
Numero sarjassa: 9
Volyymi: 52
Julkaisunumero: 9
Aloitussivu: 763
Lopetussivun numero: 781
Sivujen määrä: 19
ISSN: 0312-5963
DOI: http://dx.doi.org/10.1007/s40262-013-0070-9
Tiivistelmä
The proposed semiphysiological modelling approach generated a mechanistic description of the complex DDI occurring at major CYP3A expression sites and thus may serve as a powerful tool to maximise information acquired from clinical DDI studies. The model has been shown to draw precise and accurate predictions. Therefore, simulations based on this kind of models may be used for various clinical scenarios to improve pharmacotherapy.
The proposed semiphysiological modelling approach generated a mechanistic description of the complex DDI occurring at major CYP3A expression sites and thus may serve as a powerful tool to maximise information acquired from clinical DDI studies. The model has been shown to draw precise and accurate predictions. Therefore, simulations based on this kind of models may be used for various clinical scenarios to improve pharmacotherapy.
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