A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
PHOTIC-STIMULATION STUDY OF CHANGING THE ARTERIAL PARTIAL-PRESSURE LEVEL OF CARBON-DIOXIDE
Tekijät: SHIMOSEGAWA E, KANNO I, HATAZAWA J, FUJITA H, IIDA H, MIURA S, MURAKAMI M, INUGAMI A, OGAWA T, ITOH H, OKUDERA T, UEMURA K
Kustantaja: LIPPINCOTT-RAVEN PUBL
Julkaisuvuosi: 1995
Journal: Journal of Cerebral Blood Flow and Metabolism
Tietokannassa oleva lehden nimi: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Lehden akronyymi: J CEREBR BLOOD F MET
Vuosikerta: 15
Numero: 1
Aloitussivu: 111
Lopetussivu: 114
Sivujen määrä: 4
ISSN: 0271-678X
DOI: https://doi.org/10.1038/jcbfm.1995.12
Tiivistelmä
To investigate the effect of the level of baseline cerebral blood flow (CBF) on local CBF augmentation by activation, we have used positron emission tomography to measure regional CBF (rCBF) in 12 normal volunteers with and without photic stimulation during hypocapnia, normocapnia, and hypercapnia. The increase in rCBF in the primary visual cortex by photic stimulation was 10.8 +/- 3.1, 18.6 +/- 9.3, and 19.5 +/- 6.1 ml 100 ml(-1) min(-1) in hypo-, normo-, and hypercapnia, respectively. The increase was significantly smaller in hypocapnia than in normocapnia (p < 0.005). The fractional CBF increase caused by the photic stimulation was the same in all breathing conditions. This result indicates that the magnitude of the CBF increase induced by neuronal activity correlates proportionally with the level of baseline CBF.
To investigate the effect of the level of baseline cerebral blood flow (CBF) on local CBF augmentation by activation, we have used positron emission tomography to measure regional CBF (rCBF) in 12 normal volunteers with and without photic stimulation during hypocapnia, normocapnia, and hypercapnia. The increase in rCBF in the primary visual cortex by photic stimulation was 10.8 +/- 3.1, 18.6 +/- 9.3, and 19.5 +/- 6.1 ml 100 ml(-1) min(-1) in hypo-, normo-, and hypercapnia, respectively. The increase was significantly smaller in hypocapnia than in normocapnia (p < 0.005). The fractional CBF increase caused by the photic stimulation was the same in all breathing conditions. This result indicates that the magnitude of the CBF increase induced by neuronal activity correlates proportionally with the level of baseline CBF.
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