A1 Refereed original research article in a scientific journal
PHOTIC-STIMULATION STUDY OF CHANGING THE ARTERIAL PARTIAL-PRESSURE LEVEL OF CARBON-DIOXIDE
Authors: SHIMOSEGAWA E, KANNO I, HATAZAWA J, FUJITA H, IIDA H, MIURA S, MURAKAMI M, INUGAMI A, OGAWA T, ITOH H, OKUDERA T, UEMURA K
Publisher: LIPPINCOTT-RAVEN PUBL
Publication year: 1995
Journal: Journal of Cerebral Blood Flow and Metabolism
Journal name in source: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Journal acronym: J CEREBR BLOOD F MET
Volume: 15
Issue: 1
First page : 111
Last page: 114
Number of pages: 4
ISSN: 0271-678X
DOI: https://doi.org/10.1038/jcbfm.1995.12
Abstract
To investigate the effect of the level of baseline cerebral blood flow (CBF) on local CBF augmentation by activation, we have used positron emission tomography to measure regional CBF (rCBF) in 12 normal volunteers with and without photic stimulation during hypocapnia, normocapnia, and hypercapnia. The increase in rCBF in the primary visual cortex by photic stimulation was 10.8 +/- 3.1, 18.6 +/- 9.3, and 19.5 +/- 6.1 ml 100 ml(-1) min(-1) in hypo-, normo-, and hypercapnia, respectively. The increase was significantly smaller in hypocapnia than in normocapnia (p < 0.005). The fractional CBF increase caused by the photic stimulation was the same in all breathing conditions. This result indicates that the magnitude of the CBF increase induced by neuronal activity correlates proportionally with the level of baseline CBF.
To investigate the effect of the level of baseline cerebral blood flow (CBF) on local CBF augmentation by activation, we have used positron emission tomography to measure regional CBF (rCBF) in 12 normal volunteers with and without photic stimulation during hypocapnia, normocapnia, and hypercapnia. The increase in rCBF in the primary visual cortex by photic stimulation was 10.8 +/- 3.1, 18.6 +/- 9.3, and 19.5 +/- 6.1 ml 100 ml(-1) min(-1) in hypo-, normo-, and hypercapnia, respectively. The increase was significantly smaller in hypocapnia than in normocapnia (p < 0.005). The fractional CBF increase caused by the photic stimulation was the same in all breathing conditions. This result indicates that the magnitude of the CBF increase induced by neuronal activity correlates proportionally with the level of baseline CBF.
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