A1 Refereed original research article in a scientific journal
Galectin-3-binding protein: A multitask glycoprotein with innate immunity functions in viral and bacterial infections
Authors: Vuokko Loimaranta, Jussi Hepojoki, Olli Laaksoaho, Arto T. Pulliainen
Publisher: WILEY
Publication year: 2018
Journal: Journal of Leukocyte Biology
Journal name in source: JOURNAL OF LEUKOCYTE BIOLOGY
Journal acronym: J LEUKOCYTE BIOL
Volume: 104
Issue: 4
First page : 777
Last page: 786
Number of pages: 10
ISSN: 0741-5400
eISSN: 1938-3673
DOI: https://doi.org/10.1002/JLB.3VMR0118-036R
Abstract
Galectin-3-binding protein (Gal-3BP) is a ubiquitous and multifunctional secreted glycoprotein originally identified and mainly studied in the context of neoplastic transformation and cancer progression. However, Gal-3BP expression is induced in viral infection and by a multitude of molecules that either mimic or are characteristic for an ongoing inflammation and microbial infection, such as IFN-alpha, IFN-beta, IFN-gamma, TNF-alpha, poly(I:C), dsRNA, and dsDNA. Furthermore, Gal-3BP belongs to the scavenger receptor cysteine-rich (SRCR) domain-containing protein family, by virtue of its N-terminal SRCR domain. The SRCR domain is found in soluble or membrane-associated innate immunity-related proteins and is implicated in self-nonself discrimination. This review summarizes the current knowledge of structural features of Gal-3BP and its proposed intracellular and extracellular innate immunity functions with special emphasis on viral and bacterial infections.
Galectin-3-binding protein (Gal-3BP) is a ubiquitous and multifunctional secreted glycoprotein originally identified and mainly studied in the context of neoplastic transformation and cancer progression. However, Gal-3BP expression is induced in viral infection and by a multitude of molecules that either mimic or are characteristic for an ongoing inflammation and microbial infection, such as IFN-alpha, IFN-beta, IFN-gamma, TNF-alpha, poly(I:C), dsRNA, and dsDNA. Furthermore, Gal-3BP belongs to the scavenger receptor cysteine-rich (SRCR) domain-containing protein family, by virtue of its N-terminal SRCR domain. The SRCR domain is found in soluble or membrane-associated innate immunity-related proteins and is implicated in self-nonself discrimination. This review summarizes the current knowledge of structural features of Gal-3BP and its proposed intracellular and extracellular innate immunity functions with special emphasis on viral and bacterial infections.
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