A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
C-11-acetate PET/MRI in bladder cancer staging and treatment response evaluation to neoadjuvant chemotherapy: a prospective multicenter study (ACEBIB trial)
Tekijät: Antti Salminen, Ivan Jambor, Harri Merisaari, Otto Ettala, Johanna Virtanen, Ilmari Koskinen, Erik Veskimae, Jukka Sairanen, Pekka Taimen, Jukka Kemppainen, Heikki Minn, Peter J. Boström
Kustantaja: E-MED
Julkaisuvuosi: 2018
Journal: Cancer Imaging
Tietokannassa oleva lehden nimi: CANCER IMAGING
Lehden akronyymi: CANCER IMAGING
Artikkelin numero: ARTN 25
Vuosikerta: 18
Sivujen määrä: 9
ISSN: 1470-7330
eISSN: 1470-7330
DOI: https://doi.org/10.1186/s40644-018-0158-4
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/35711531
Background: To evaluate the accuracy of C-11-acetate Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) in bladder cancer (BC) staging and monitoring response to neoadjuvant chemotherapy (NAC).Methods: Eighteen patients were prospectively enrolled. Fifteen treatment naive patients underwent C-11-acetate PET/MRI before transurethral resection of bladder tumor (TUR-BT) for primary tumor evaluation. Five patients with muscle invasive BC were imaged after NAC and prior to radical cystectomy (RC) with extended pelvic lymph node dissection (ePLND) for NAC treatment response evaluation. Two patients were part of both cohorts. C-11-acetate PET/MRI findings were correlated with histopathology. Accuracy for lymph node detection was evaluated on patient and the ePLND template (10 regions) levels.Results: The sensitivity, specificity and accuracy of C-11-acetate PET/MRI for the detection of muscle invasive BC was 1.00, 0.69 and 0.73 while the area under the receiver operating characteristic curve (95% confidence interval) was 0.85 (0.55-1.0), respectively. All five NAC patients underwent chemotherapy as planned and C-11-acetate PET/MRI correctly staged three patients, overstaged one and understaged one patient compared with RC and ePLND findings. A total of 175 lymph node were removed, median of 35 (range, 27-43) per patient in five patients who had RC and ePLND while 12 (7%) harboured metastases. Sensitivity, specificity, accuracy and AUC for N-staging were 0.20, 0.96, 0.80 and 0.58 on the ePLND template (10 regions) level.Conclusions: C-11-acetate PET/MRI is feasible for staging of BC although sensitivity for the detection of nodal metastases is low. Monitoring response to NAC shows promise and warrants evaluation in larger studies.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
