A2 Refereed review article in a scientific journal

Identifying therapeutic targets from spontaneous beneficial brain lesions



Authors: Joutsa J, Shih LC, Horn A, Reich MM, Wu O, Rost NS, Fox MD

Publisher: WILEY

Publication year: 2018

Journal: Annals of Neurology

Journal name in source: ANNALS OF NEUROLOGY

Journal acronym: ANN NEUROL

Volume: 84

Issue: 1

First page : 153

Last page: 157

Number of pages: 5

ISSN: 0364-5134

eISSN: 0364-5134

DOI: https://doi.org/10.1002/ana.25285

Web address : 10.1002/ana.25285

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/35658786


Abstract
Brain damage can occasionally result in paradoxical functional benefit, which could help identify therapeutic targets for neuromodulation. However, these beneficial lesions are rare and lesions in multiple different brain locations can improve the same symptom. Using a technique called lesion network mapping, we show that heterogeneous lesion locations resulting in tremor relief are all connected to common nodes in the cerebellum and thalamus, the latter of which is a proven deep brain stimulation target for tremor. These results suggest that lesion network mapping can identify the common substrate underlying therapeutic lesions and effective therapeutic targets. Ann Neurol 2018;83:153-157

Downloadable publication

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.


Last updated on 2024-26-11 at 15:44