Neuropeptide Y polymorphism increases the risk for asthma in overweight subjects; protection from atherosclerosis in asthmatic subjects--the cardiovascular risk in young Finns study

: Jaakkola U, Kakko T, Juonala M, Lehtimäki T, Viikari J, Jääskeläinen AE, Mononen N, Kähönen M, Koskinen T, Keltikangas-Järvinen L, Raitakari O, Kallio J

Publisher: CHURCHILL LIVINGSTONE

: 2012

: Neuropeptides

: NEUROPEPTIDES

: 6

: 46

: 6

: 321

: 328

: 8

: 0143-4179

DOI: https://doi.org/10.1016/j.npep.2012.09.005

Conclusions: Overweight together with the NPY-399T allele without NPY-Pro7 allele was associated with increased risk for asthma. Atherosclerosis was decreased in subjects with asthma depending on the NPY genotype. The results reveal novel insights into the genetics and biology of the relationship of atherosclerosis and asthma. (C) 2012 Elsevier All rights reserved.