A2 Refereed review article in a scientific journal
Heterogeneity of Muscle Blood Flow and Metabolism: Influence of Exercise, Aging, and Disease States
Authors: Heinonen I, Koga S, Kalliokoski KK, Musch TI, Poole DC
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Publication year: 2015
Journal: Exercise and Sport Sciences Reviews
Journal name in source: EXERCISE AND SPORT SCIENCES REVIEWS
Journal acronym: EXERC SPORT SCI REV
Volume: 43
Issue: 3
First page : 117
Last page: 124
Number of pages: 8
ISSN: 0091-6331
eISSN: 1538-3008
DOI: https://doi.org/10.1249/JES.0000000000000044
The systematic increase in VO2 uptake and O-2 extraction with increasing work rates conceals a substantial heterogeneity of O-2 delivery (QO(2))-to- VO2 matching across and within muscles and other organs. We hypothesize that whether increased/decreased QO(2)/VO2 heterogeneity can be judged as "good" or "bad," for example, after exercise training or in aged individuals or with disease (heart failure, diabetes) depends on the resultant effects on O-2 transport and contractile performance.
