B1 Non-refereed article in a scientific journal
Mechanism of pH-independent cleavage and isomerization of 3 '-ribonucleotide phosphodiesters
Authors: Kosonen M, Lonnberg H
Publisher: MARCEL DEKKER INC
Publication year: 1999
Journal:Nucleosides & nucleotides
Journal name in sourceNUCLEOSIDES & NUCLEOTIDES
Journal acronym: NUCLEOS NUCLEOT
Volume: 18
Issue: 4-5
First page : 1099
Last page: 1100
Number of pages: 2
ISSN: 0732-8311
DOI: https://doi.org/10.1080/15257779908041658
Abstract
The detailed mechanisms of pH-independent cleavage and isomerization reactions of the phosphodiester bond are evaluated by examining kinetics of hydrolytic reactions of selected mono- and dialkyl esters of 3'-uridylic acid. The mechanistic choices are made by comparing LFER's between reaction rates and acidity of the alkyl group of phosphodi- and triesters.
The detailed mechanisms of pH-independent cleavage and isomerization reactions of the phosphodiester bond are evaluated by examining kinetics of hydrolytic reactions of selected mono- and dialkyl esters of 3'-uridylic acid. The mechanistic choices are made by comparing LFER's between reaction rates and acidity of the alkyl group of phosphodi- and triesters.
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